Gene Therapy 2019 | London | UK | Allied Conferences | Call for Abstracts

Cell Therapy or cytotherapy is the transfer of cells into a patient with a goal of improving the disease. From beginning blood transfusions were considered to be the first type of cell therapy to be practised as routine. Later, Bone Marrow Transplantation has also become a well-established concept which involves treatment of much kind of blood disorders including anaemia , leukaemia, lymphoma and rare immunodeficiency diseases. Alternative medical practitioners perform cell therapy in the form of several different names including xenotransplant therapy, glandular therapy, and fresh cell therapy. It has been claimed by the proponents of cell therapy that it has been used successfully to repair spinal cord injuries, strengthen weaken immune system, treats autoimmune diseases like AIDS, help patients with neurological disorders like Alzheimer’s disease, Parkinson’s disease and epilepsy.

Related Conferences: 2nd World Congress on Stem Cells and Regenerative Medicine, March 14-15, 2019, London, UK | International Conference on Molecular Biology and Stem Cells, November 19-20, 2018, Paris, France | World Congress on Tissue Engineering and Regenerative Medicine, March 14-15, 2019, London, UK | 10th International Conference on Genomics and Molecular Biology May 21-23, 2018, Barcelona, Spain

Gene therapy is unique technique used in medical treatment that uses specific types of genes to treat several types of diseases. Gene therapy is also used to treat several hereditary diseases, wherein the mutated defective gene is replaced with the functional gene. Gene therapy is the one which most vast topic carried out by researchers all over the world for the prevent or treat of several diseases such as immune deficiencies, hemophilia, Parkinson’s disease, cancer, and even HIV, through different approaches. Three primary approaches that are being studied and practiced in the gene therapy are replacement of the mutated disease-causing gene with the healthy gene, inactivation of the mutated gene, and introduction of the new gene to fight against the disease. In the gene therapy treatment, a functional gene is inserted into the genome of an individual’s cells and tissues by using a carrier known as ‘vector’. Viruses is the most common type of vectors used in gene therapy, which is genetically altered to carry the normal human DNA. Over the last few years, gene therapy has emerged as a promising treatment option for several diseases including inherited disorders and certain types of cancers and viral infections.

Related Conferences: 2nd World Congress on Stem Cells and Regenerative Medicine, March 14-15, 2019, London, UK | International Conference on Molecular Biology and Stem Cells, November 19-20, 2018, Paris, France | World Congress on Tissue Engineering and Regenerative Medicine, March 14-15, 2019, London, UK | 10th International Conference on Genomics and Molecular Biology May 21-23, 2018, Barcelona, Spain

Cardiovascular diseases have become an increasing clinical issue globally. A new challenge in the treatment of the cardiovascular disease is cellular transplantation or cellular cardiomyoplasty. Acute ischaemic injury and chronic cardiomyopathies lead to permanent loss of cardiac tissue and ultimately heart failure. Current therapies wide aim to attenuate the pathological changes that occur when injury and to scale back risk factors of vas diseases. However, they do not improve the patient's quality of life or the prognosis more than moderate. Different types of stem cells have been used for stem cell therapy.

Related Conferences: 2nd World Congress on Stem Cells and Regenerative Medicine, March 14-15, 2019, London, UK | International Conference on Molecular Biology and Stem Cells, November 19-20, 2018, Paris, France | World Congress on Tissue Engineering and Regenerative Medicine, March 14-15, 2019, London, UK | 10th International Conference on Genomics and Molecular Biology May 21-23, 2018, Barcelona, Spain

Cell Therapy is defined as the therapy in which cellular material is injected into a patient in order to recover the healthy tissue. Cell therapy is targeted at many clinical indications in multiple organs by means of several modes of cell delivery. Stem-Cell Therapy is the use of stem cells to treat or prevent a disease or condition. Stem cells are a class of undifferentiated cells which are able to differentiate into required or specialized cell types. Adult or somatic stem cells exist throughout the body after embryonic development and are found available inside the different types of tissue. The stem cell methodology includes the phases of Stem cell or progenitor cell engraftment, differentiation followed by long term replacement of damaged tissue.

Related Conferences: 2nd World Congress on Stem Cells and Regenerative Medicine, March 14-15, 2019, London, UK | International Conference on Molecular Biology and Stem Cells, November 19-20, 2018, Paris, France | World Congress on Tissue Engineering and Regenerative Medicine, March 14-15, 2019, London, UK | 10th International Conference on Genomics and Molecular Biology May 21-23, 2018, Barcelona, Spain

The extract derived from the plant cell culture technology is being harnessed and utilized as an active ingredient in anti-aging skincare products. In recent years, researchers have identified naturally occurring botanicals with substantial antioxidant activity proven to protect skin stem cells from UV-induced oxidative stress, inhibit inflammation, neutralize free radicals and reverse the effects of photoaging by means of anti-oxidant activity. Consequently, cosmeceutical products containing plant stem cell derived extracts have the ability to promote healthy cell proliferation and protect against UV-induced dermatological cellular damage in humans. In contrast to epidermal stem cells, plant stem cells are totipotent that they are capable of regenerating an entirely new, whole plant. Through innovative plant stem cell technology, scientists are able to extract tissue from botanicals and regenerate stem cells can be harnessed for use in humans. The use of stem cells derived from botanicals plant, rather than human stem cells, avoids the controversy surrounding the source or methods of extraction of human stem cells while still harnessing the potential of these intriguing cells and its effect in anti photoaging.

Related Conferences: 2nd World Congress on Stem Cells and Regenerative Medicine, March 14-15, 2019, London, UK | International Conference on Molecular Biology and Stem Cells, November 19-20, 2018, Paris, France | World Congress on Tissue Engineering and Regenerative Medicine, March 14-15, 2019, London, UK | 10th International Conference on Genomics and Molecular Biology May 21-23, 2018, Barcelona, Spain

Tissue science is basically study and understanding of how the tissue is arranged in a complexed human system and its structure and functions of it. As we all know that all the tissues are grouped together to form the organ.so its all important to know about the tissues first.

Regenerative medicine is the part of translational research in tissue engineering and molecular biology. it deals with the "process of replacing, engineering or regenerating human cells, tissues or organs to restore or establish normal function". This field contains the hope of engineering damaged tissues and organs. Regenerative medicine is having the possibility of growing tissues and organs in the laboratory and implanting them in order to give the capacity to the body to heal by itself. If a regenerated organ's cells are basically derived from the patient's own tissue or cells, this would help to puzzle out the problem of the shortage of organs available for donation, and the problem of organ transplant rejection.

Related Conferences: 2nd World Congress on Stem Cells and Regenerative Medicine, March 14-15, 2019, London, UK | International Conference on Molecular Biology and Stem Cells, November 19-20, 2018, Paris, France | World Congress on Tissue Engineering and Regenerative Medicine, March 14-15, 2019, London, UK | 10th International Conference on Genomics and Molecular Biology May 21-23, 2018, Barcelona, Spain

Epigenetics refers to changes in a chromosome which has influence on gene activity and expression. It is also used to describe any heritable phenotypic change that doesn't derive from a modification of the chromosome such as prions. Epigenetics is the mechanism for storing and perpetuating or continuing indefinitely a “memory” at the cellular level. The basic molecular epigenetic mechanisms that are widely studied at present – regulation of chromatin structure of cell through histone post-translational modifications and covalent modification of DNA principally through the method of DNA methylation. Chromatin is a dynamic structure that integrates potentially hundreds of signals from the cell surface and has effects of coordinated and appropriate transcriptional response in cell. It is increasingly clear that epigenetic marking of chromatin and DNA itself is an important component of the cell signal integration of entire function that is performed by the genome. Moreover, the changes in the epigenetic state of chromatin in cell can have lasting effects on behavioral changes.

Related Conferences: 2nd World Congress on Stem Cells and Regenerative Medicine, March 14-15, 2019, London, UK | International Conference on Molecular Biology and Stem Cells, November 19-20, 2018, Paris, France | World Congress on Tissue Engineering and Regenerative Medicine, March 14-15, 2019, London, UK | 10th International Conference on Genomics and Molecular Biology May 21-23, 2018, Barcelona, Spain

Diseases can be treated using viruses used as vector to deliver genes .In gene therapy viruses act as gene vector, however, can themselves cause problems in that they may initiate inflammation and the genes may be expressed at too high a level or for too long period of exposure. The goal of nano technology in gene therapy is delivery of therapeutic genes without a virus, using nanoparticles as non-viral vector to deliver the genes. The particles can be made with multiple layers so the outer layer with covering of peptide that can target the particles to cells of interest at specific site. The emerging technology called Nanotechnology which is used in gene therapy in order to develop unique approaches in treating the retinopathies and the development of micro and nano dimensional artificial antigen presenting cells (aAPCs) for cancer immunotherapy. These aAPCs mimic the natural signals in immunity that killer T-cells receive when there is an invader (bacteria, virus, cancer cell, etc.) in the body.

Related Conferences: 2nd World Congress on Stem Cells and Regenerative Medicine, March 14-15, 2019, London, UK | International Conference on Molecular Biology and Stem Cells, November 19-20, 2018, Paris, France | World Congress on Tissue Engineering and Regenerative Medicine, March 14-15, 2019, London, UK | 10th International Conference on Genomics and Molecular Biology May 21-23, 2018, Barcelona, Spain

Classical methods of gene therapy include transfection. It became inefficient and limited mainly due to delivery of gene into actively proliferating cell s invitro. Gene therapy utilizes the delivery of DNA into cells by means of vectors such as biological invitro or viral vectors and non-viral methods. The Several kinds of viruses vectors used in gene therapy are retrovirus, adeno-associated virus and herpes simplex virus. While other recombinant viral vector systems have been developed,retroviral vectorsremain the most popular vector system for gene therapy protocols and widest application due to their historical significance as the first vectors developed for efficient gene therapy application and the infancy of the field of gene therapy.

Related Conferences: 2nd World Congress on Stem Cells and Regenerative Medicine, March 14-15, 2019, London, UK | International Conference on Molecular Biology and Stem Cells, November 19-20, 2018, Paris, France | World Congress on Tissue Engineering and Regenerative Medicine, March 14-15, 2019, London, UK | 10th International Conference on Genomics and Molecular Biology May 21-23, 2018, Barcelona, Spain

Genome editing technology deals with engineered nucleases and it is the emerging type of genetic engineering. it is the technology in which the DNA is inserted, deleted or replaced in the genome. The emergence of highly versatile genome-editing technologies has provided investigators with the ability to rapidly and economically introduce sequence-specific modifications into the genomes of a broad spectrum of cell types and organisms. It also promotes various changes in sub cellular level.genome editing itself also holds tremendous potential for treating the underlying various idiopathic genetic causes of certain diseases. The core technologies now most commonly used techniques to facilitate genome editing are clustered regularly interspaced short palindromic repeats (CRISPR)-CRISPR-associated protein 9 (Cas9), transcription activator-like effector nucleases (TALENs), zinc-finger nucleases (ZFNs), and homing endonucleases or meganucleases.

Related Conferences: 2nd World Congress on Stem Cells and Regenerative Medicine, March 14-15, 2019, London, UK | International Conference on Molecular Biology and Stem Cells, November 19-20, 2018, Paris, France | World Congress on Tissue Engineering and Regenerative Medicine, March 14-15, 2019, London, UK | 10th International Conference on Genomics and Molecular Biology May 21-23, 2018, Barcelona, Spain

Tissue engineering is the combinational usage of cells, engineering, materials methods, suitable biochemical and physicochemical factors in order to improve or replace the infected biological tissues. The field includes the development of materials, devices, techniques to detect and differentiate disease states ,the treatment response, aid tissue healing, precisely deliver treatments to tissues or cells, signal early changes in health status, and provide implantable bio artificial replacement organs for recover or establish of healthy tissue .Techniques developed here identify and detect biomarkers of disease sub-types, progression, and treatment response, from tissue imaging,gene testing and gene analysis, that aid the more rapid development of new treatments and guide their clinical applications in treating the disorder. It includes the usage of computational modeling,bioinformatics and quantitative pharmacology to integrate data from diverse experimental and clinical sources to discover new drugs and specific drug targets, as well as to design more efficient and informative preclinical, clinical safety and efficacy studies.

Related Conferences: 2nd World Congress on Stem Cells and Regenerative Medicine, March 14-15, 2019, London, UK | International Conference on Molecular Biology and Stem Cells, November 19-20, 2018, Paris, France | World Congress on Tissue Engineering and Regenerative Medicine, March 14-15, 2019, London, UK | 10th International Conference on Genomics and Molecular Biology May 21-23, 2018, Barcelona, Spain

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Session on: Cell Therapy

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Session on: Cell Therapy of Cardiovascular Disorders

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Session on: Tissue Science and Regenerative Medicine

Session on: Molecular Basis of Epigenetics

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